The incorrect description of biotransformation is: After biotransformation, the toxicity of foreign compounds is reduced.
1. Description of Biotransformation:
Biotransformation refers to the metabolic transformation of foreign compounds into metabolites. After biotransformation, their water solubility generally increases and they can be easily excreted. be divided into There are two broad categories of phase I reactions and phase II reactions, and biotransformation occurs mainly in the liver. Other tissues also have biotransformation capabilities, called extrahepatic metabolism.
2. Biotransformation Definition:
Biological transformation refers to the metabolic process in which the chemical structure of poisons changes after being catalyzed by enzymes, that is, the poisons undergo qualitative changes . ?
The transferBiological formation is an important event that occurs before the elimination of poisons in the body. Its typical result is the production of non-toxic or low-toxic metabolites. Therefore, biotransformation and detoxification were once equated.
The most important pathway in the biological transformation process
1 Biotransformation is the metabolic transformation of exogenous chemicals in the body catalyzed by various enzymes;
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2. Biotransformation is an important part of the body's elimination of exogenous chemicals
3. It is the body’s primary maintenance mechanism; homeostasis There are many non-nutritional substances in the human body. Before excreting these non-nutritional substances, the body will biotransform them to increase their water capacity and polarity, making them easier to excrete through urine or bile and to eliminate toxic substances. the body.
Biological transformation refers to the metabolic process in which the chemical structure of poisons changes after being catalyzed by enzymes, that is, the poisons undergo qualitative changes. Biotransformation is an important event that occurs before a poison is eliminated from the body, and its typical result is the production of nontoxic or minimally toxic metabolites. Therefore, biotransformation and detoxification were once equated. However, in many cases, biotransformation produces toxic metabolites that can cause tissue damage. The biological transformation at this time is called biological activation. Also known as poisoning, it is a chemical transformation process that occurs when foreign compounds are catalyzed enzymatically or non-enzymatically in the body. Biotransformation pcan reduce the toxicity of foreign compounds through biological detoxification, and can also increase the toxicity of some foreign compounds (bioactivation), which is generally called the dual nature of biotransformation. For example, soil microorganisms can convert lindane into carbon dioxide, while underwater microorganisms can convert inorganic mercury into the more toxic methylmercury. The biological transformation of organic matter is the energy and matter necessary to maintain biological activities. Artificial inert organic matter is generally difficult to process by organisms and pollute the environment. The process of absorption, distribution and excretion of chemical poisons in the body is called biological transport [1].
The process of metabolic changes in chemicals is called biological transformation. The liver is the main organ ofe biotransformation. Enzymes related to biotransformation are present in liver cell microsomes, cytosol, mitochondria and other parts. Other tissues such as the kidneys, gastrointestinal tract, lungs, skin, and placenta can also undergo some biotransformation, but the liver is the most important and has the strongest biotransformation function.