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International
Standard
ISO 16000-33
Second edition
Indoor air —
2024-07
Part 33:
Determination of phthalates
with gas chromatography/mass
spectrometry (GC/MS)
Air intérieur —
Partie 33: Détermination des phthalates par chromatographie en
phase gazeuse/spectrométrie de masse (CPG/SM)
Reference number
© ISO 2024
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ii
Contents Page
Foreword .v
Introduction .vi
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Abbreviated terms . 2
5 Sampling methods and analytical apparatus. 3
5.1 General .3
5.2 Sampling by adsorption with subsequent thermal desorption .3
5.2.1 Apparatus, operating materials and chemicals .3
5.2.2 Preparation of the thermal desorption tube .4
5.2.3 Sampling .4
5.3 Sampling by adsorption and subsequent solvent extraction .5
5.3.1 Apparatus, operating materials and chemicals .5
5.3.2 Preparation of Florisil and the adsorption tubes .6
5.3.3 Suggestions regarding the application of Florisil .6
5.3.4 Sampling .7
5.3.5 Sample conditioning .7
6 Calibration . 8
6.1 General .8
6.2 Calibration of the thermal desorption method .8
6.3 Calibration of the solvent extraction method .8
7 Identification and quantification . 9
7.1 Mass spectrometric analysis .9
8 Establishment of calibration curves and calculation of the analyte mass. 14
8.1 Establishment of a calibration curve .14
8.2 Calculation of the analyte mass . .14
9 Calculation of indoor air concentrations .15
10 Performance characteristics . 16
10.1 Detection limit .16
10.2 Quantification limit and problems related to blank values .16
10.3 Reproducibility standard deviation and repeatability standard deviation .17
11 Quality assurance .18
11.1 Method verification and determination of blanks .18
11.1.1 General .18
11.1.2 Field blank value of the indoor air .18
11.1.3 Analytical laboratory blank value .18
11.2 Measures for blank value minimization .18
11.3 Documents.19
12 Interferences . 19
Annex A (informative) General information on phthalates .20
Annex B (informative) Sampling by adsorption with ODS solid phase disk or SDB copolymer
cartridge .23
Annex C (informative) Screening phthalates in solvent wipe tests .29
Annex D (informative) Screening phthalates in house dust .32
Annex E (informative) Practical example for the calibration of the thermal desorption method .36
iii
Annex F (informative) Practical example for the calibration of the solvent extraction method
using Florisil .38
Annex G (informative) Practical example for the gas chromatography with thermal desorption .40
Annex H (informative) Practical example for the gas chromatography following solvent
extraction . 41
Annex I (informative) Problems related to the blank values .42
Annex J (informative) Example of sampling protocol documentation .43
Bibliography .44
iv
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
bodies (ISO member bodies). The work of preparing International Standards is normally carried out through
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in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the different types
of ISO document should be noted. This document was drafted in accordance with the editorial rules of the
ISO/IEC Directives, Part 2 (see www.iso.org/directives).
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This document was prepared by Technical Committee ISO/TC 146, Air quality, Subcommittee SC 6, Indoor air.
This second edition cancels and replaces the first edition (ISO 16000-33:2017), which has been technically
revised.
The main change is as follows: a description of an adsorbent which can alternatively be used has been added.
A list of all parts in the ISO 16000 series can be found on the ISO website.
Any feedback or questions on this document should be directed to the user’s national standards body. A
complete listing of these bodies can be found at www.iso.org/members.html.
v
Introduction
Different parts of the ISO 16000 series describe the general requirements relating to the measurement of
indoor air pollutants and the important conditions to be observed before or during the sampling of individual
pollutants or groups of pollutants, as well as the measurement procedures themselves.
The definition of indoor environment is given by ISO 16000-1. Dwellings [living rooms, bedrooms, do-it-
yourself (DIY) rooms, sports rooms and cellars, kitchens and bathrooms], workrooms or workplaces in
buildings which are not subject to health and safety inspections with respect to air pollutants (e.g. offices,
salesrooms), public buildings (e.g. restaurants, theatres, cinemas and other meeting rooms) and passenger
cabins of motor vehicles and public transport are among the
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